Fenben lab fenbendazol is used to treat worms in dogs, cats, horses and other mammals. It is most commonly used to treat gastrointestinal nematodes such as pinworms, giardia, roundworms, hookworms and pulmonary paragonimiasis.
It also has cytostatic and antitumor activities in cell culture models and animal tumors. It acts by blocking polymerization of tubulin, which makes up microtubules, and is similar to cytotoxic anticancer agents such as vinca alkaloids and taxanes.
Benefits
While some cancer patients have claimed that fenbendazole or another drug in the benzimidazole family, including mebendazole and praziquantel, can help prevent or cure cancer, there is no scientific evidence that this claim is true. The only reliable way to determine if a medication is effective against cancer is to conduct a clinical trial that includes a control group. While some studies using tumor cells in a laboratory dish or mice have found that fenbendazole can inhibit the growth of certain types of cancer, these findings haven’t been replicated in humans.
A 2018 study reported that mebendazole, a drug in the benzimidazole carbamate family that’s similar to fenbendazole, can reduce breast cancer cell growth in an animal model. However, this study was limited by the fact that it was conducted in a single patient with advanced non-small cell lung cancer who self-administered mebendazole.
The anthelmintic fenbendazole (methyl N-(6-phenylsulfanyl-1H-benzimidazole-2-yl) carbamate) is used in laboratory experiments to study the behavior and effects of parasites on host organisms. It is a broad-spectrum anthelmintic and can be administered to many different species of animals, making it easy to use in laboratory experiments. The anthelmintic also has a high safety margin and is well-tolerated by most species of animals. In experiments, fenbendazole reduced the clonogenicity of EMT6 cancer cells by reducing the number of colonies and the total cell volume. This indicates that fenbendazole may have cytostatic as well as cytotoxic properties against EMT6 cancer cells.
Dosage
Fenbendazole is a broad-spectrum benzimidazole anthelmintic approved for use in many animal species. It is used in cattle to remove the adult forms of Haemonchus contortus and Ostertagia ostertagi and to control the growth of the arrested fourth-stage forms of these parasites. It also controls lungworms (Metastrongylus apri, Metastrongylus pudendotectus) and nodular worms (Stephanurus dentatus).
The drug works by binding to tubulin in the cell, disrupting its microtubule equilibrium, and inhibiting its polymerization. The result is that the cells are unable to function, and they die. This is thought to be one of the reasons fenbendazole has such success as an antiparasitic medication, although Health Feedback found evidence that it does not kill cancer cells by this method.
A small amount of fenbendazole is taken orally by humans for parasitic infestations. It is well-tolerated and does not cause any significant side effects. The dose is generally taken three times a day for 10 days. The results have been promising, but more research is needed to determine whether fenbendazole can be used as an alternative to conventional therapies for cancer in people.
Studies have been conducted to see if the drug can affect radiation therapy in cancerous cells. Using the EMT6 glioblastoma multiforme tumor model, mice were treated with either a placebo or fenbendazole and exposed to low-doses of radiation. Treatment with fenbendazole prior to and during radiation did not alter the radiation dose-response curve in either aerobic or hypoxic cells.
Side Effects
Fenbendazole is an antiparasitic drug used to treat parasitic infections in dogs, cats, horses, rabbits, and rats. It is also being studied to see if it can help prevent and treat certain cancers. Some studies suggest that fenbendazole can slow the growth of cancer cells in laboratory experiments with cultured tumors and animals. But there is no evidence that it can cure cancer in people. The nonprofit organization Cancer Research UK tells PolitiFact that while fenbendazole can indeed inhibit the growth of some cancer cells in petri dishes and mice, “there is no credible evidence from randomized clinical trials to show that fenbendazole can cure or treat cancer in humans.”
Fenbendazoles work by interfering with the formation of microtubules, a protein scaffold that provides structure and shape to cells. Textbook depictions of cells often portray them as organelles floating in amorphous bags of liquid, but cells establish shape and structure through a protein framework called the cytoskeleton, which is comprised of microtubules.
One study in which a human lung adenocarcinoma cell line was treated with fenbendazole showed that the drug can inhibit the invasiveness of the cancer cells and significantly reduce tumor size and weight. The researchers also observed that fenbendazole suppresses RAS-related signaling pathways in the same cell line, which may contribute to its antitumor activity.
Fenbendazole is also widely used as an antiparasitic drug in dogs and other veterinary species to treat pinworms, giardiasis, roundworms, hookworms, whipworms, Taenia solium, and pulmonoscopy paragonimiasis. It does not interact with the hepatitis B virus or other hepatic enzymes and is safe for use in pregnant women and children. However, fenbendazole should not be given concurrently with bromsalan flukicides, as this combination has been shown to cause abortions in cattle and death in sheep.
Warnings
Fenben lab fenbendazol is a medication that should be stored in a cool, dry place away from sunlight. It should be kept out of reach of children and pets. Always follow your veterinarian’s instructions for proper storage and disposal of this medication. If your animal experiences side effects or if you suspect an overdose, contact your vet immediately. Fenbendazol is one of the most popular wormers available in the market. It is also a popular choice for the eradication of pinworm infections in laboratory rodent colonies.